Reference: Garber, M. et al., Identifying novel constrained elements by exploiting biased substitution patterns. Bioinformatics 25, i54-62, doi:btp190 [pii] 10.1093/bioinformatics/btp190 (2009).
Heights (omega, pi)
Summary: These files contain base-level measure of constraint scored using SiPhy (see reference above), both as a rate-based score (omega) and a measure that includes biased substitution patterns (pi).
Files (warning, VERY LARGE):
omega.12mers.wig.gz (10.8 Gb)
Format: ‘position log_odds_score’
pi.ewig.gz (25.6 Gb)
Format: postion %A %C %G %G log_odds_score effective_branch_length tree_bit
effective_branch_length: Remaining branch length after prunning the phylogentic tree for gaps and missing sequence
tree_big: Unique integer representing the leaves remainng after prunning.
Contact: Manuel Garber