Less than ~1.2% of the 3 billion bases of the human genome encodes genes that are translated into proteins. Yet, a much larger percentage encodes functional genetic elements. Many of these functional elements control how genes are regulated to produce specific patterns of expression in different tissues and cell types. Precisely how these elements work remains an open question in biology. Our lab strives to understand the non coding landscape of the genome.
The Garber laboratory is also home to the University of Massachusetts Medical School bioinformatics core. The Bioinformatics core website implements robust pipelines for the analyis of next generation sequencing data available to all research laboratories on campus.